Hepatoprotective Sesquiterpenes and Rutinosides from Murraya koenigii (L.) Spreng

Three new sesquiterpenes (1-3) and two new rutinosides (4 and 5) along with 17 known compounds (6-22) were isolated from the leaves of Murraya koenigii (L.) Spreng. The new compounds were elucidated as (3R,5S,6R)-3,5,6-trihydroxy-1,1,5-trimethylcyclohexyl-8-butyn-9-one (1), (8E,9R)-ethyl-7-(3S,5R,6S)-3,6-dihydroxy-1,1,5-trimethylcyclohexyl-9-hydroxybut-8-enoate (2), (3R)-3-O-beta-D-glucoside-6'-D-apiose-beta-ionone (3), 4-O-beta-D-rutinosyl-3-methoxyphenyl-1-propanone (4), and 1-O-beta-D-rutinosyl-2(R)-ethyl-1-pentanol (5) based on their spectroscopic data. Compounds 1, 4, 5, 18, and 21 (10 mu M) exhibited moderate hepatoprotective activities.