Journal
NANO LETTERS
Volume 15, Issue 5, Pages 3080-3087Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.5b00073
Keywords
Gold nanoparticles; intrinsically disordered proteins; neurofilaments; small-angle X-ray scattering; spectroscopy
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Funding
- Israeli Science Foundation [571/11]
- European Community [CIG - 293402]
- Tel Aviv University Center for Nanoscience and Nanotechnology
- Abramson Center for Medical Physics
- Sackler Institute for Biophysics at Tel Aviv University
- Legacy fund (ISF)
- Marian Gertner Institute for Medical Nanosystems fellowship
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The structural plasticity of intrinsically disordered proteins serves as a rich area for scientific inquiry. Such proteins lack a fix three-dimensional structure but can interact with multiple partners through numerous weak bonds. Nevertheless, this intrinsic plasticity possesses a challenging hurdle in their characterization. We underpin the intermolecular interactions between intrinsically disordered neurofilaments in various hydrated conditions, using grafted gold nanoparticle (NP) tags. Beyond its biological significance, this approach can. be applied to modify the surface interaction of NPs for the creation of future tunable smart hybrid biomaterials.
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