Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 62, Issue 49, Pages 11917-11923Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf504128c
Keywords
Paecilomyces gunnii; phenalenones; tyrosinase inhibiton
Funding
- China National Science Foundation [30871676]
- Foundation of the Ministry of Science and Technology of Anhui Province [1408085MC46, KJ2012A107]
- Anhui Agricultural University Talents Foundation [YJ2011-06]
- Anhui Outstanding Youth Science Foundation [1108085J04]
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Through screening 50 strains of entomopathogenic fungi and rescreening of 7 strains of Paecilomyces gunnii, a methanol extract of liquid-cultivated mycelia of P. gunnii was found to have the strongest tyrosinase inhibitory activity. Preparative high-speed counter-current chromatography (HSCCC) guided by high-performance liquid chromatography (HPLC)-electrospray ionization (ESI)-high-resolution mass spectrometry (HRMS) was employed for the isolation and purification of the active components, and three new compounds with half inhibition concentration (IC50) of 0.11, 0.17, and 0.14 mM against diphenolase were obtained from the extract, respectively. Their chemical structures were identified by HRMS, one- and two-dimensional nuclear magnetic resonance (2D NMR) spectroscopy as paecilomycones A, B, and C. Structure and activity studies showed that the tyrosinase inhibition activities are positively related to the number of hydroxyl groups on the paecilomycones.
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