Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 61, Issue 31, Pages 7560-7567Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf402218z
Keywords
bifidobacteria; Bifidobacterium animalis; galacto-cligosaccharides; gut microbiota; lactulose; prebiotic
Funding
- Spanish Council for Scientific Research (CSIC) from the Ministerio de Ciencia e Innovacion [PIF-SIALOBIOTIC 200870F010-1, PIF-SIALOBIOTIC 200870F010-2, PIF-SIALOBIOTIC 200870F010-3]
- ERDF from Junta de Comunidades de Castilla-La Mancha [POII10-0178-4685]
- Junta de Andalucia [AGR-7626]
- Spanish National Research Council (CSIC, JAE-Doc Programme)
- COST Action
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There is increasing interest in identifying novel dietary nondigestible carbohydrates capable of modulating the composition and/or metabolic activities of the gut microbiota. This work assessed the differential modulatory influence of novel galacto-oligosaccharides derived from lactulose (GOS-Lu) in comparison with commercial galacto-oligosaccharides derived from lactose (GOS-La) in gut microbiota of growing rats (5 weeks old). Rats were fed either a control diet or diets containing 1% (w/w) of GOS-Lu or GOS-La, and cecal and colonic contents were collected after 14 days of treatment. Compared to controls, GOS-Lu had significantly more bifidobacteria within the large intestine, showing a significant and selective increase of Bifidobacterium animalis in the cecum and colon; however, no significant differences in the number of bifidobacteria among GOSLu and GOS-La groups were observed. Both types of GOS significantly increased the number of the Eubacterium rectale/Clostridium coccoides group. These findings support a prebiotic role of galactosyl-fructoses in functional foods.
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