Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 61, Issue 47, Pages 11434-11441Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf4032519
Keywords
sour cherry; Prunus cerasus L.; nectar processing; anthocyanins; in vitro; bioavailability; Caco-2 cell model
Funding
- EU 7th Frame ATHENA Project [FP7-KBBE-2009-3-245121-ATHENA]
- Dutch Ministry of Economic Affairs, Agriculture Innovation
- CBSG under the auspices of The Netherlands Genomics Initiative
- NMC under the auspices of The Netherlands Genomics Initiative
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Anthocyanins can contribute to human health through preventing a variety of diseases. The uptake of these compounds from food and the parameters determining uptake efficiency within the human body are still poorly understood. Here we have employed a Caco-2 cell based system to investigate the transport of key antioxidant food components from sour cherry (Prunus cerasus L.) across the intestinal epithelial barrier. Anthocyanins and (-)-epicatechin were supplied in three contrasting matrices: fruit, processed fruit cherry juice, and polyphenolic fractions obtained by solid-phase extraction. Results show that both compound types behave differently. Fruit or juice matrices display comparable transport across the epithelial cell layer. The juice supplements sucrose and citric acid, which are regularly added to processed foods, have a positive effect on stability and transport. Polyphenolic fractions display a lower transport efficiency, relative to that of the fruit or juice, indicating the importance of food matrix components for intestinal absorption of polyphenols.
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