Journal
NANO LETTERS
Volume 15, Issue 12, Pages 8407-8411Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.5b04566
Keywords
DNA nanotechnology; molecular devices; enzymes; DNA nanostructures
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Funding
- Associazione Italiana per la Ricerca sul Cancro, AIRC [14420]
- European Research Council, ERC [336493]
- Int. Research Staff Exchange Scheme (IRSES)
- Italian Ministry of Health [GR-2010-2317212]
- Italian Ministry of University and Research [2012CTAYSY]
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Functional molecular nanodevices and nanomachines have attracted a growing interest for their potential use in life science and nanomedicine. In particular, due to their versatility and modularity DNA-based nanodevices appear extremely promising. However, a limitation of such devices is represented by the limited number of molecular stimuli and cues that can be used to control and regulate their function. Here we demonstrate the possibility to rationally control and regulate DNA-based nanodevices using biocatalytic reactions catalyzed by different enzymes. To demonstrate the versatility of our approach, we have employed three model DNA-based systems and three different enzymes (belonging to several classes, i.e., transferases and hydrolases). The possibility to use enzymes and enzymatic substrates as possible cues to operate DNA-based molecular nanodevices will expand the available toolbox of molecular stimuli to be used in the field of DNA nanotechnology and could open the door to many applications including enzyme-induced drug delivery and enzyme-triggered nanostructures assembly.
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