Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 61, Issue 14, Pages 3419-3427Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf304790a
Keywords
peroxisome proliferator-activated receptor gamma (PPAR gamma); tomato extracts; polyphenols; carotenoids; fatty acids; luciferase reporter gene assay; mixture effects
Funding
- Food and Nutrition Delta [FND07007]
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Since beneficial effects related to tomato consumption partially overlap with those related to peroxisome proliferator-activated receptor gamma (PPAR gamma) activation, our aim was to test extracts of tomato fruits and tomato components, including polyphenols and isoprenoids, for their capacity to activate PPAR gamma using the PPAR gamma 2 CALUX reporter cell line. Thirty tomato compounds were tested; seven carotenoids and three polyphenols induced PPAR gamma 2-mediated luciferase expression. Two extracts of tomato, one containing deglycosylated phenolic compounds and one containing isoprenoids, also induced PPAR gamma 2-mediated expression at physiologically relevant concentrations. Furthermore, enzymatically hydrolyzed extracts of seven tomato varieties all induced PPAR gamma-mediated expression, with a 1.6-fold difference between the least potent and the most potent variety. The two most potent varieties had high flavonoid content, while the two least potent varieties had low flavonoid content. These data indicate that extracts of tomato are able to induce PPAR gamma-mediated gene expression in vitro and that some tomato varieties are more potent than others.
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