Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 61, Issue 9, Pages 2171-2182Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf3049774
Keywords
limonoids; fungicidal activity; insecticidal activity; Aphanamixis polystachya; Meliaceae
Funding
- National Natural Science Foundation of China [21272275]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Program for Changjiang Scholars and Innovative Research Team in University [PCSIRT-IRT1193]
- Fundamental Research Funds for the Central Universities [JKY2011011]
- Syngenta Postgraduate Fellowship [SPF-048-1]
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Seven new prieurianin-type limonoids, aphapolynins C-I (1-7), and a new aphanamolide-type limonoid, aphanamolide B (8), along with seventeen known compounds, were isolated from the fruits of Aphanamixis polystachya. The structures of these compounds were established on the basis of spectroscopic studies. The absolute configurations were determined by combination of electronic circular dichroism (ECD) calculation, CD exciton chirality method, and single crystal X-ray diffraction. All these isolates were evaluated for their cytotoxicities against three human cancer cell lines, for their inhibitory effects on lipopolysaccharide (LPS) induced RAW264.7 murine macrophages, and for their fungicidal, herbicidal, and insecticidal activities. Compounds 1, 14, 16, and 17 exhibited significant fungicidal activities; 1 and 25 in particular showed good insecticidal activities. The alpha,beta-unsaturated lactone and 14,15-epoxy ring moieties were essential for the insecticidal activity.
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