Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 60, Issue 29, Pages 7142-7151Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf3006867
Keywords
Lactobacillus; microbial catabolism; flavan-3-ols; B-type procyanidins; A-type procyanidins; grape seed extract; cranberry extract
Funding
- Spanish Ministry for Science and Innovation [AGL2009-13361-C02-00, AGL2010-17499, CSD2007-00063]
- Comunidad de Madrid [ALIBIRD P2009/AGR-1469]
- CYTED [IBEROFUN 110AC0386]
- JAE-Doc Program (CSIC)
- Danone Institute
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Lactobacillus plantarum IFPL935 was incubated with individual monomeric flavan-3-ols and dimeric A- and B-type procyanidins to identify new metabolites and to determine the effect of compound structural features on bacterial growth and catabolism. Complex extracts rich in A-type proanthocyanidins and phenolic acids from cranberry were also tested. The results showed that L. plantarum IFPL935 exhibited higher resistance to nongalloylated monomeric flavan-3-ols, A-type dimeric procyanidins, and cranberry extract than to (-)-epicatechin-3-O-gallate and B-type dimeric procyanidins. Despite these findings, the strain was capable of rapidly degrading (-)-epicatechin-3-O-gallate, but not A- or B-type dimeric procyanidins. However, it was able to produce large changes in the phenolic profile of the cranberry extract mainly due to the catabolism of hydroxycinnamic and hydroxybenzoic acids. Of most relevance was the fact that L plantarum IFPL935 cleaved the heterocyclic ring of monomeric flavan-3-ols, giving rise to 1-(3',4'-dihydroxyphenyl)-3-(2 '',4 '',6 ''-trihydroxyphenyl)propan-2-ol, activity exhibited by only a few human intestinal bacteria.
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