Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 60, Issue 36, Pages 9305-9314Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf302179c
Keywords
carnosic acid; carnosol; rosmarinic acid; rosemary extract in fish oil; degradation study; HPLC analysis
Funding
- Alcon Research, Ltd.
- Robert A. Welch Foundation [Y-0026]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0840509] Funding Source: National Science Foundation
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Rosemary, whose major caffeoyl-derived and diterpenoid ingredients are rosmarinic acid, carnosol, and carnosic acid, is an important source of natural antioxidants and is being recognized increasingly as a useful preservative, protectant, and even as a potential medicinal agent. Understanding the stability of these components and their mode of interaction in mixtures is important if they are to be utilized to greatest effect. A study of the degradation of rosmarinic acid, carnosol, carnosic acid, and a mixture of the three was conducted in ethanolic solutions at different temperatures and light exposure. As expected, degradation increased with temperature. Some unique degradation products were formed with exposure to light. Several degradation products were reported for the first time. The degradation products were identified by HPLC/MS/MS, UV, and NMR. The degradation of rosemary extract in fish oil also was investigated, and much slower rates of degradation were observed for carnosic acid. In the mixture of the three antioxidants, carnosic acid serves to maintain levels of carnosol, though it does so at least in part at the cost of its own degradation.
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