4.7 Article

Lignans from the Root of Rhodiola crenulata

Journal

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 60, Issue 4, Pages 964-972

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jf204660c

Keywords

Rhodiola crenulata; lignan; isolation; health food; alpha-glucosidase

Funding

  1. National Natural Science Foundation of China [30973861]
  2. Nation Science and Technology Project of China [2009YZH-HXY07]

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Rhodiola crenulata L. is an important species in genus Rhodiola widely used as a health food to reinforce immunity, improve memory and learning, scavenge active-oxygen species, and relieve altitude sickness. Eleven new lignans and a new benzonitrile compound, crenulatanoside A, were isolated from the roots of R. crenulata L. along with 25 known compounds, including 12 lignans. The structures of these compounds were elucidated by spectroscopic data and chemical evidence. Among them, compounds 1-4 and 5-7 were determined to be optical isomers of two 8-O-4' neolignan glycosides. Compounds 8-11 were aryl tetralin type lignans, and compounds 12 and 13 were dihydrobenzofuran neolignans. All of the isolated compounds were evaluated for their inhibitory activity against a-glucosidase. From the data obtained, compound 37 showed strong inhibitory activity against alpha-glucosidase with an IC50 value of 96.8 mu M.

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