Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 60, Issue 25, Pages 6359-6363Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf301440u
Keywords
beta-agonists; liquid chromatography-tandem mass spectrometry; matrix effects; porcine tissues and urine
Funding
- National Natural Science Foundation of China [31072166]
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The synergistic influences of analyte concentration, sample source, and solid-phase extraction (SPE) type on matrix effects in the multiresidue analyses of eight beta-agonists with LC-ESI-MS/MS were evaluated. Porcine muscle and liver extracts and urine from diverse sources were purified by strong or mixed-mode cation exchange and molecularly imprinted polymer SPE cartridges, respectively. Three spiked concentrations (2, 10, and 20 ng/mL) of eight beta-agonists in the purified matrices and the different sample sources were analyzed. The results show that for most beta-agonists there are significant differences in matrix effects between analyte concentrations or sample sources (P < 0.05), whereas there is no significant difference in matrix effects between different SPE cartridges (P > 0.05). Results from main effects testing indicated that analyte concentration was the main effector.
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