Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 60, Issue 42, Pages 10546-10554Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf302809k
Keywords
apple; triterpene; procyanidin; nutrigenomics; inflammation
Funding
- New Zealand Ministry for Science and Innovation as part of Nutrigenomics New Zealand [C06X0702]
- Fond National de la Recherche Luxembourg [PDR 08033]
Ask authors/readers for more resources
We evaluated the potential of apple to reduce inflammation. Phenolic compounds and triterpenes were analyzed in 109 apple cultivars. Total phenolics ranged from 29 to 7882 mu g g(-1) of fresh weight (FW) in the flesh and from 733 to 4868 mu g g(-1) FW in the skin, with flavanols including epicatechin and procyanidins as major components. Ursolic (44.7 to 3522 mu g g(-1) FW) and oleanolic (47.2 to 838 mu g g(-1) FW) acids dominated the skin triterpene profile. Five chemically contrasting cultivars were fractionated and their immune-modulating activity measured using two cell-based assays targeting key points in the inflammation process. Cultivars exhibiting high contents of procyanidins were the most potent at inhibiting NF-kappa B while triterpene-rich fractions reduced the promoter activity of the gene of TNF alpha. This study provides new insights into how apple genetic diversity could be used to alleviate inflammation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available