Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 60, Issue 21, Pages 5400-5406Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf3014475
Keywords
oleifolioside A; apoptosis; AIF; EndoG; HeLa
Funding
- Ministry for Food, Agriculture, Forestry
- Fisheries of the Republic of Korea
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science, and Technology [2010-0001730]
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Apoptosis, the main type of programmed cell death, plays an essential role in a variety of biological events. Whereas classical apoptosis is dependent on caspase activation, caspase-independent death is increasingly recognized as an alternative pathway. To develop new anticancer agents, oleifolioside A was isolated from Dendropanax morbifera Leveille and the biochemical mechanisms of oleifolioside A-induced apoptosis in HeLa cells were investigated. Exposure to oleifolioside A resulted in caspase activation and typical features of apoptosis, although cell death was not prevented by caspase inhibition. Oleifolioside A treatment induced up-regulation of Bad, loss of mitochondrial membrane potential, nuclear relocation of mitochondrial factors, apoptosis-inducing factor (AIF), endonuclease G (EndoG), and apoptosis induction. This is the first report of anticancer activity of oleifolioside A, and nuclear translocation of AIF and EndoG in oleifolioside A-treated HeLa cells might represent an alternative death signaling pathway in the absence of caspase activity.
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