Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 60, Issue 9, Pages 2171-2178Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf204625y
Keywords
antiallergic food; naringenin; phytochemicals; Tregs
Funding
- Japan Society for the Promotion of Science [22658040]
- Grants-in-Aid for Scientific Research [24580176, 22658040, 21380077, 22780115] Funding Source: KAKEN
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The aryl hydrocarbon receptor (AhR), a transcription factor mediating xenobiotic detoxification, plays a considerable role in regulatory T cell (Treg) induction. Tregs regulate the immune system, thus suppressing allergies and autoimmune diseases. This study aims to identify new types of antiallergic dietary factors, with focus on the flavonoids with potential AhR agonistic activity. Among 25 dietary flavonoid samples tested using a reporter assay, 8 showed marked induction of AhR-dependent transcriptional activity. The subsequent T cell proliferation suppression assay identified naringenin as the only sample capable of stimulating Treg induction; notably, this induction was eliminated by cotreatment with AhR antagonists. Indeed, naringenin induced CD4(+)Foxp3(+) Tregs, irrespective of the presence of the transforming growth factor-beta (TGF-beta), indicating that the conventional TGF-beta-dependent signaling pathway might not be involved.
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