Journal
NANO LETTERS
Volume 15, Issue 8, Pages 5530-5538Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.5b02099
Keywords
Nanomembranes; rolled-up nanotechnology; 3D cell culture scaffold; spatial confinement; neural stem cells; cell migration
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Funding
- Volkswagen Foundation [86 362]
- European Research Council (ERC)
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We employ glass microtube structures fabricated by rolled-up nanotechnology to infer the influence of scaffold dimensionality and cell confinement on neural stem cell (NSC) migration. Thereby, we observe a pronounced morphology change that marks a reversible mesenchymal to amoeboid migration mode transition. Space restrictions preset by the diameter of nanomembrane topography modify the cell shape toward characteristics found in living tissue. We demonstrate the importance of substrate dimensionality for the migration mode of NSCs and thereby define rolled-up nanomembranes as the ultimate tool for single-cell migration studies.
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