Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 59, Issue 21, Pages 11862-11871Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf2029016
Keywords
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Funding
- U S National Institutes of Health [RO1 CA120915, CA120915 S2, RO1 CA122474, RO1 CA1330217]
- National Cancer Institute Cancer Center [CA72720]
- National Institute of Environmental Health Center [ES05022]
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The aim of this study was to investigate the effects of (-)-epigallocatechin-3-gallate (EGCG) on newly developed high-fat/Western-style diet-induced obesity and symptoms of metabolic syndrome Male C57BL/6J mice were fed a high fat/Western-style (HFW, 60% energy is fat and lower levels of calcium, vitamin D-3, folic acid, choline bitartrate, and fiber) or HFW with EGCG (HFWE, HFW with 0 32% EGCG) diet for 17 wks As a comparison, two other groups of mice fed a low-fat diet (LF, 10% energy as fat) and high-fat diet (HF, 60% energy as fat) were also included The HFW group developed more body weight gain and severe symptoms of metabolic syndrome than the HF group The EGCG treatment significantly reduced body weight gain associated with increased fecal lipids and decreased blood glucose and alanine aminotransferase (ALT) levels compared to those of the HFW group Fatty liver incidence, liver damage, and liver triglyceride levels were also decreased by the EGCG treatment Moreover, the EGCG treatment attenuated insulin resistance and levels of plasma cholesterol, monocyte chemoattractant protein-1 (MCP-1), C-reactive protein (CRP), interlukin-6 (IL-6), and granulocyte colony-stimulating factor (G-CSF) Our results demonstrate that the HFW diet produces more severe symptoms of metabolic syndrome than the HF diet and that the EGCG treatment can alleviate these symptoms and body fat accumulation The beneficial effects of EGCG are associated with decreased lipid absorption and reduced levels of inflammatory cytokines
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