Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 59, Issue 21, Pages 11690-11695Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf202544w
Keywords
Zingiber officinale; Tongling White Ginger; gingerdione dimers; gingerol derivatives; 11 beta-HSD
Funding
- National Basic Research Program of China (973 Program) [2009CB522300]
- National Natural Sciences Foundation of China [30830113]
- MOST [2009ZX09501-029]
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Gingerols and their corresponding dehydration products shogaols were considered as the active principles of ginger, the rhizome of the plant Zingiber officinale, for its antioxidant, ant-inflammatory, and antitumor activities Ginger (Z. officinale) has been cultivated for thousands of years as a spice and for medicinal purposes in China. Tongling (Anhui province, China) has traditionally been regarded as an ideal cultivation place Tongling White Ginger enjoys a reputation for being one of the top gingers in China for its thin white peel, tender flesh, rich juice, and flavor In this study, we have isolated and identified two novel gingerdione dimers, bisgingerdiones A (1) and B (2), two new gingerol derivatives, (5R)-5-acetoxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptan-3-one (3) and methyl (Z)-neral acetal-[6]-gingerdiol (4), and 38 known compounds (5-42) from rhizomes of Zingiber officinale collected from Tongling, China. Their structures were elucidated by means of spectroscopic methods Compounds 1-4 showed weak cytotoxic and anti-HIV-1 activities Compounds 6, 8, and 26 showed inhibitory activities against human and mouse 11 beta-HSD1 (11 beta-hydroxysteroid dehydrogenases) with IC50 values between 1 09 and 1 30 mu M.
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