Journal
ANNUAL REVIEW OF PSYCHOLOGY, VOL 66
Volume 66, Issue -, Pages 853-876Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-psych-010814-015340
Keywords
magnetic resonance imaging; diffusion tensor imaging; brain development; white matter; myelination; infancy
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Funding
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB000975, P41EB015909] Funding Source: NIH RePORTER
- NIBIB NIH HHS [R01 EB000975, P41 EB015909] Funding Source: Medline
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The human brain rapidly develops during the final weeks of gestation and in the first two years following birth. Diffusion tensor imaging (DTI) is a unique in vivo imaging technique that allows three-dimensional visualization of the white matter anatomy in the brain. It has been considered to be a valuable tool for studying brain development in early life. In this review, we first introduce the DTI technique. We then review DTI findings on white matter development at the fetal stage and in infancy as well as DTI applications for understanding neurocognitive development and brain abnormalities in preterm infants. Finally, we discuss limitations of DTI and potential valuable imaging techniques for studying white matter myelination.
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