Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 58, Issue 18, Pages 9988-9993Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf101926j
Keywords
Dalbergia odorifera; Pueraria thunbergiana; Leguminosae; yeast alpha-glucosidase; isoflavone
Funding
- Korea Research Council for Industrial Science & Technology (KOCI)
- Korea Forest Service, Korea [S120808L1101104]
- Korea Forest Service [S120808L1101104] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In the course of searching for new classes of alpha-glucosidase inhibitors originated from natural resources, 11 kinds of isoflavones, i.e., medicarpin (1), formononetin (2), mucronulatol (3), (3R)-calussequinone (5), (3R)-5'-methoxyvestitol (6), tectorigenin (7), biochanin A (8), tuberosin (9), calycosin (10), daidzein (11), and genistein (12), as well as a flavone, liquritigenin (4), were isolated as active principles responsible for the yeast a-glucosidase inhibitory activity from two leguminous plant extracts, i.e., the heartwood extract of Dalbergia odorifera and the roots extract of Pueraria thunbergiana. Each components (1-12) demonstrated a significantly potent inhibition on yeast alpha-glucosidase in a dose dependent manner when the p-nitrophenyl-alpha-D-glucopyranoside was used as a substrate in vitro. The concentration required for 50% enzyme inhibition (IC50) were calculated as 2.93 mM (1), 0.51 mM (2), 3.52 mM (7) 0.35 mM (8), 3.52 mM (9), 0.85 mM (11), and 0.15 mM (12) when that of reference drug acarbose was evaluated as 9.11 mM, in vitro. However, isoflavone glycosides, i.e., puerarin (13), daidzin (14), formononetin-7-O-beta-glucopyranoside (15), and genistin (16), exhibited a relatively poor inhibitory activity on yeast alpha-glucosidase as compared with the corresponding isoflavone (2, 11, 12), respectively
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