Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 58, Issue 6, Pages 3316-3321Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf904091d
Keywords
Elsholtzia splendens; chitosan nanoparticles; loading efficiency; antioxidant activity; beta-carotene bleaching assay
Funding
- National Research Foundation of Korea [2009-0094018, 핵09A2907] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Elsholtzia splendens extract-loaded chitosan nanoparticles prepared by ionic gelation were characterized by particle size, zeta potential, entrapment efficiency, and loading efficiency. As the initial concentration of E splendens extract was increased, the loading efficiency and zeta potential significantly increased, whereas the entrapment efficiency and particle size significantly decreased. The optimum concentration of E splendens extract for maximum loading efficiency was found to be 0.8 mg/mL. Both free E splendens extract and E. splendens extract-loaded chitosan nanoparticles showed concentration-dependent antioxidant activity. However, the lipid peroxidation inhibitory activity of E. splendens extract was effectively enhanced when it was entrapped within chitosan nanoparticles. Chitosan nanoparticle encapsulation is therefore a potentially valuable technique for improving the antioxidant activity of E splendens extract.
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