Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 58, Issue 22, Pages 11525-11533Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf1031789
Keywords
Domoic acid; shellfish poisoning; determination; sample preparation; HPLC; CE; CEC
Funding
- National Nature Sciences Foundation of China [20735002, 20877019, 40940026]
- Foundation from the Sino-German Center for Research Promotion
- Ministry of Education of China [708056]
- Nature Sciences Funding of Fujian Province [2008J0228, 2007F5068]
- China Scholarship Council
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Domoic acid (DA), a neurotoxic amino acid produced by some strains of phytoplankton, is responsible for the human toxic syndrome amnesic shellfish poisoning. This exocitotoxin results in neuronal degeneration and necrosis in specific regions of the hippocampus. Because DA accumulates mostly in shellfish, causing outbreaks in different countries, screening for DA has been carried out with various assays. Although bioassays and immunoassays have been developed, several liquid chromatographic methods for the determination of DA in different matrices such as shellfish, algae, or seawater have been reported. Additionally, other alternative methods such as capillary electrophoresis and capillary electrochromatography have been described. This paper summaries the toxicology, the chemistry, and the developed determination methods of DA.
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