Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 58, Issue 23, Pages 12337-12342Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf103440s
Keywords
Phenanthrene-based tylophorine derivatives; synthesis; antiviral activities; tobacco mosaic virus; Inhibitors
Funding
- National Key Project for Basic Research [2010CB126100]
- National Natural Science Foundation of China [20872072]
- China Postdoctoral Science Foundation [20090460057]
Ask authors/readers for more resources
A series of C9-substituted phenanthrene-based tylophorine derivatives (PBTs) were designed, synthesized, and first evaluated for their antiviral activities against tobacco mosaic virus (TMV). These compounds contain a phenanthrene core structure and can be synthesized some efficiently with excellent y elds compared with tylophorine alkaloid. The bioassay results show that some of these compounds exhibited higher antiviral activity against TMV in vivo than tylophorine and commercial Ningnanmycin. Especially, compounds 3, 4, 9, 13, and 16 emerged as potential inhibitors of plant virus. These new findings demonstrate that these phenanthrene-based tylophorine derivatives (PBTs) represent another new template for antiviral studies and could be considered for novel therapy against plant virus infection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available