Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 58, Issue 6, Pages 3847-3854Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf904563c
Keywords
[8]-Shogaol; human leukemia HL-60 cells; apoptosis; reactive oxygen species
Funding
- National Science Council [NSC 98-2313-B-022-002-MY3, NSC 98-2622-B-127-001-CC3]
- NIH [CA138277]
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Ginger, the rhizome of Zingiber officinale, is a traditional medicine with a carminative effect and antinausea, anti-inflammatory, and anticarcinogenic properties. This study examined the growth inhibitory effects of [8]-shogaol, one of the pungent phenolic compounds in ginger, on human leukemia HL-60 cells. It demonstrated that [8]-shogaol was able to induce apoptosis in a time- and concentration-dependent manner. Treatment with [8]-shogaol caused a rapid loss of mitochondrial transmembrane potential, stimulation of reactive oxygen species (ROS) production, release of mitochondrial cytochrome c into cytosol, and subsequent induction of procaspase-9 and procaspase-3 processing. Taken together, these results suggest for the first time that ROS production and depletion of glutathione that contributed to [8]-shogaol-induced apoptosis in HL-60 cells.
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