Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 56, Issue 17, Pages 7678-7681Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf801252s
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Funding
- Sigrid Juselius Foundation and Folkhalsan, Helsinki, Finland
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This study presents the optimization and validation of a rapid protocol for quantifying alkyresorcinol (AR) metabolites 3,5-dihydroxybenzoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA) in plasma, using high-performance liquid chromatography (HPLC) coupled with a coulometric electrode array detector. Syringic acid (SyrA) serves as the internal standard. The new method is simple and could be used in large epidemiological studies. The summed AIR metabolite concentrations measured in plasma correlate significantly with the summed urinary AIR metabolite concentrations (R = 0.613; p < 0.001) and with the summed intact AR (C17:0-C25:0) concentrations in plasma (R = 0.686; p < 0.001). Additional investigation is needed to clarify whether the two plasma AR metabolites are useful as biomarkers of whole-grain intake and helpful in the exploration of the association between whole-grain cereal intake and human diseases.
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