Journal
JOURNAL OF AFFECTIVE DISORDERS
Volume 157, Issue -, Pages 100-103Publisher
ELSEVIER
DOI: 10.1016/j.jad.2013.11.019
Keywords
Major depressive disorder; Circadian rhythm; Clock genes; Cry1; Tef
Categories
Funding
- National Natural Science [81170309]
- Key Project of Medical Science and Technology Development Foundation from Nanjing Department of Health [200905016]
Ask authors/readers for more resources
Introduction: Accumulating evidences indicate that circadian abnormalities lead to sleep disorder, neurodegenerative diseases and depression. We have reported that the polymorphisms of a clock-related gene. Tef, contributed to the risk of sleep disturbances and depression in the Parkinson disease. The objective of the present study was to examine whether the three clock genes we previously studied are associated with major depressive disorder (MDD) in the Chinese population. Methods: 105 Subjects with MDD and 485 control subjects participated in this case-control study. Demographics, Mini-mental Status Examination (MMSE), and the Hamilton rating scale for depression (HAMD) were obtained in all subjects. Genotypes of single nucleotide polymorphisms (SNPs) of Cry1 rs2287161, Cry2 rs10838524 and Tef rs738499 were screened by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: MOD cases had a significantly higher frequency carrying the C allele and CC genotype in Cry1 rs2287161 and the T allele and TT genotype in Tef rs738499 than controls. Limitations: The sample size of MDD group was relatively small. Conclusions: The polymorphisms of Cry1 rs2287161 and Tef rs738499 are associated to MOD. (C) 2014 Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available