Journal
ANNUAL REVIEW OF PHYSIOLOGY, VOL 77
Volume 77, Issue -, Pages 13-27Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-physiol-021014-071641
Keywords
mesenchymal stem cells; microRNA; lung vascular disease; regenerative medicine; secretome
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Mesenchymal stem cells (MSCs), whose mechanism of action is predominantly paracrine, are being widely tested for the treatment of a variety of human diseases. No one factor has been proven sufficient to mediate the therapeutic effects of MSCs. However, exosomes-membrane vesicles secreted by many cells, including MSCs-are appealing candidates as vectors of their efficacy. Exosomes can transport and deliver a large cargo of proteins, lipids, and nucleic acids and can modify cell and organ function. In addition to their key role as vehicles of intercellular communication, exosomes are increasingly recognized as biomarkers and prognosticators of disease. Moreover, they have the potential to be used as vehicles of gene and drug delivery for clinical application. This article reviews the biogenesis of exosomes, their molecular composition, and their role as messengers of intercellular communication, focusing on their potential as therapeutic vectors for stem cell therapy.
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