Journal
JOURNAL OF AFFECTIVE DISORDERS
Volume 141, Issue 2-3, Pages 294-299Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jad.2012.03.035
Keywords
Corpus callosum; Hippocampus; Depression; Magnetic resonance imaging; Child abuse; Elderly
Categories
Funding
- regional government of Languedoc-Roussillon
- Agence Nationale de la Recherche [ANR 07-LVIE-004]
- Novartis
- France Alzheimer
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Childhood adversity has been observed to engender structural changes in the hippocampus and corpus callosum associated with increased risk for depression in childhood and early adulthood. This study investigated this association in the elderly. Corpus callosum area and hippocampal volume were measured from structural MRI in 427 community dwelling elderly. Information on childhood adversity was obtained in the course of a clinical examination using a questionnaire covering multiple aspects of abuse. Multivariate analyses found a significant increase in corpus callosum area and hippocampal volume in subjects exposed to mental disorder in parents and poverty, respectively. No association was found with childhood sexual and physical abuse. (C) 2012 Elsevier B.V. All rights reserved.
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