Journal
ANNUAL REVIEW OF PHYSIOLOGY, VOL 77
Volume 77, Issue -, Pages 323-345Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-physiol-021113-170343
Keywords
uric acid; hyperuricemia; URAT1; SLC2A9; ABCG2
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Uric acid, generated from the metabolism of purines, has proven and emerging roles in human disease. Serum uric acid is determined by production and the net balance of reabsorption or secretion by the kidney and intestine. A detailed understanding of epithelial absorption and secretion of uric acid has recently emerged, aided in particular by the results of genome-wide association studies of hyperuricemia. Novel genetic and regulatory networks with effects on uric acid homeostasis have also emerged. These developments promise to lead to a new understanding of the various diseases associated with hyperuricemia and to novel, targeted therapies for hyperuricemia.
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