Journal
JOURNAL OF AFFECTIVE DISORDERS
Volume 134, Issue 1-3, Pages 315-319Publisher
ELSEVIER
DOI: 10.1016/j.jad.2011.06.003
Keywords
Anxiety; Trait; Cortical thickness; Orbitofrontal cortex; NAcc; Fear conditioning
Categories
Funding
- German Federal Ministry of Education and Research (BMBF) [01G508159]
- AstraZeneca
- Eli Lilly Co
- Janssen-Cilag
- Bristol-Myers Squibb
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Structural deficiencies within the medial prefrontal cortex have been shown in anxiety-related psychiatric disorders such as panic disorder, post traumatic stress disorder and obsessive compulsive disorder. In healthy subjects, trait anxiety as the individual's disposition to experience anxiety-relevant feelings or thoughts has been shown to be a risk factor for psychiatric disorders. We aimed at exploring the structural correlates of trait anxiety in normal participants. We acquired high-resolution MRI scans from 34 subjects and used FreeSurfer to obtain a measure of cortical thickness. We correlated cortical thickness with self-rated trait anxiety in a whole brain analysis. Automatic subcortical segmentations of the FreeSurfer pipeline were used to relate nucleus accumbens (NAcc) and amygdala volume to trait anxiety. Trait anxiety was negatively correlated with cortical thickness in the right medial orbitofrontal cortex (mOFC) and positively correlated with the bilateral volume of NAcc. Cortical thickness measures extracted from mOFC were negatively associated with the volume of left NAcc. Since, like in anxiety-related psychiatric disorders, in the healthy sample studied here, trait anxiety was associated with a reduction of cortical thickness in mOFC we suggest that this thinning is a structural precondition rather than a consequence of psychiatric illnesses. (C) 2011 Elsevier B.V. All rights reserved.
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