Journal
ANNUAL REVIEW OF PHYSICAL CHEMISTRY, VOL 66
Volume 66, Issue -, Pages 357-377Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-physchem-040214-121802
Keywords
infrared spectroscopy; site-specific probe; vibrational coupling; isotope editing; unnatural amino acid; vibrational Stark effect spectroscopy
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Funding
- NIGMS NIH HHS [P41 GM104605, R01 GM065978, GM-008275, GM-065978, T32 GM008275, P41-GM104605] Funding Source: Medline
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Infrared spectroscopy has played an instrumental role in the study of a wide variety of biological questions. However, in many cases, it is impossible or difficult to rely on the intrinsic vibrational modes of biological molecules of interest, such as proteins, to reveal structural and environmental information in a site-specific manner. To overcome this limitation, investigators have dedicated many recent efforts to the development and application of various extrinsic vibrational probes that can be incorporated into biological molecules and used to site-specifically interrogate their structural or environmental properties. In this review, we highlight recent advancements in this rapidly growing research area.
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