Journal
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
Volume 766, Issue -, Pages 32-41Publisher
ELSEVIER
DOI: 10.1016/j.mrrev.2015.07.003
Keywords
Mycotoxins; Carcinogenesis; Mycotoxin co-exposure; Mycotoxin carcinogenicity; Colorectal cancer; Hepatocellular cancer
Funding
- Flemish Agency for Innovation by Science and Technology (IWT) [141177]
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Mycotoxins, toxic secondary metabolites of fungi, affect global agriculture so prolifically that they are virtually ubiquitous at some concentration in the average human diet. Studies of in vitro and in vivo toxicity are discussed, leading to investigations of co-exposed mycotoxins, as well as carcinogenic effects. Some of the most common and toxicologically significant mycotoxins, such as the aflatoxins, ochratoxins, fumonisins, deoxynivalenol, T-2 toxin, HT-2 toxin, patulin, zearalenone, and some ergot alkaloids are outlined. The wide variety of pathogenic mechanisms these compounds employ are shown capable of inducing a complex set of interactions. Of particular note are potential synergisms between mycotoxins with regard to carcinogenic attributable risk, indicating an important field for future study. (C) 2015 Elsevier B.V. All rights reserved.
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