Journal
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
Volume 794, Issue -, Pages 25-31Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mrgentox.2015.09.005
Keywords
Anemia; DNA damage; Genotoxicity; Hematopoietic system; Rat; Titanium dioxide nanoparticles
Funding
- Ministere Tunisien de l'Enseingement Superieur et de la Recherche Scientifique [UR12ES10]
Ask authors/readers for more resources
Titanium dioxide nanoparticles (TiO2 NPs) are widely used for their whiteness and opacity. We investigated the hematological effects and genotoxicity of anatase TiO2 NPs following sub-chronic oral gavage treatment. TiO2-NPs were characterized by X-ray diffractometry (XRD), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM). Wistar rats were treated with anatase TiO2 NPs by intragastric administration for 60 days. Hematological analysis showed a significant decrease in RBC and HCT and a significant increase in MCV, PLT, MPV and WBC at higher doses. Furthermore, abnormally shaped red cells, sometimes containing micronuclei, and hyper-segmented neutrophil nuclei were observed with TiO2 NPs treatment. The micronucleus test revealed damage to chromosomes in rat bone marrow at 100 and 200 mg/kg bw; the comet assay showed significant DNA damage at the same doses. (C) 2015 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available