Journal
MUSCLE & NERVE
Volume 52, Issue 2, Pages 240-244Publisher
WILEY-BLACKWELL
DOI: 10.1002/mus.24527
Keywords
exercise; fatigue; motor neuron disease; neuromuscular disorders; SMA III; spinal muscular atrophy type III; training
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Funding
- A.P. Moller Foundation for the Advancement of Medical Science
- Vanfore Foundation
- Hans and Nora Buchards Foundation
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IntroductionIn this study we investigated the effect of 12 weeks of cycle ergometer training in patients with spinal muscular atrophy type III (SMA III), a hereditary motor neuron disease with progressive muscle weakness and atrophy. MethodsSix SMA III patients and 9 healthy subjects completed a 12-week training program, performing 42 30-minute sessions exercising at 65-70% of maximal oxygen uptake (VO2max). VO2max, muscle strength, functional tests, and self-reported activities of daily living were assessed before and after the training. ResultsTraining induced a 273% increase in VO2max (17 +/- 2 to 21 +/- 2 ml/kg/min, P < 0.001) in patients. However, fatigue was a major complaint and caused 1 patient to drop out, increased the need for sleep in 3 patients, and led to training modifications in 2 patients. ConclusionsCycle exercise improves VO2max in SMA III without causing muscle damage, but it also induces significant fatigue. This warrants study into alternative training methods to improve exercise capacity in SMA III patients. Muscle Nerve52: 240-244, 2015
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