Journal
MUSCLE & NERVE
Volume 52, Issue 1, Pages 137-139Publisher
WILEY-BLACKWELL
DOI: 10.1002/mus.24630
Keywords
ALS; amyotrophic lateral sclerosis; MR neurography; MRI; multifocal motor neuropathy
Categories
Funding
- NCI NIH HHS [K08 CA169443, K08-CA 169443] Funding Source: Medline
Ask authors/readers for more resources
Introduction: Magnetic resonance imaging (MRI) of peripheral nerve and muscle in patients with amyotrophic lateral sclerosis (ALS) may be performed to investigate alternative diagnoses, including multifocal motor neuropathy (MMN). MRI findings of peripheral nerve and muscle are not well described in these conditions, making interpretation of results difficult. Methods: We examined systematically the peripheral nerve and muscle MRI findings in patients with ALS (n=60) and MMN (n=8). Results: In patients with ALS and MMN, abnormal MRIs were common (85% and 75%, respectively), but did not correlate with disease severity. Peripheral nerve MRI abnormalities were similar in frequency (ALS 58%, MMN 63%), with most changes being of mild to moderate severity. Muscle MRI changes were more common in ALS (57% vs. 33%), and no muscle atrophy was seen in patients with MMN. Conclusion: MRI abnormalities of peripheral nerve and muscle in ALS and MMN are common and share some features.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available