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Sum Frequency Generation Studies on Bioadhesion: Elucidating the Molecular Structure of Proteins at Interfaces

Journal

JOURNAL OF ADHESION
Volume 85, Issue 8, Pages 484-511

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/00218460902996374

Keywords

Bioadhesion; Factor XII; Fibrinogen; Interfaces; Interfacial proteins; Mussel adhesive protein; Sum frequency generation vibrational spectroscopy

Funding

  1. Office of Naval Research [N00014-02-1-0832, N-00014-08-1-1211]
  2. National Science Foundation [CHE-0449469]
  3. National Institute of Health [1R01GM081655-01A2]
  4. University of Michigan
  5. NSF
  6. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM081655] Funding Source: NIH RePORTER

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The study of bioadhesion is significant to applications in a variety of scientific fields. Techniques that are surface-sensitive need to be utilized to examine these kinds of systems because bioadhesion occurs at the interface between two surfaces. Recently, sum frequency generation (SFG) has been applied to investigate different bioadhesive processes because of its intrinsic surface specificity, excellent sensitivity, and its ability to perform experiments in situ. SFG studies on the bioadhesion of fibrinogen, Factor XII, and mefp-3 on various surfaces will be discussed in this review.

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