Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 21, Issue 10, Pages 1332-1343Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458515572405
Keywords
Multiple sclerosis; cognitive impairment; cognitive rehabilitation tools; brief repeatable battery of neuropsychological tests; MS-Line; neurorehabilitation
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Funding
- Biogen Idec
- Merck Serono
- Bayer Healthcare
- Teva Pharmaceutical Industries
- 'La Caixa' (Spain)
- Fundacion Obra Social Caja Madrid (Spain)
- Academia de Ciencies Mediques i de la Salut de Catalunya i de Balears (Spain)
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Background: MS-Line! was created to provide an effective treatment for cognitive impairment in multiple sclerosis (MS) patients. Objective: To assess the efficacy of MS-Line!. Methods: A randomized, controlled, single-blind, 6-month pilot study. Patients were randomly assigned to an experimental group (cognitive rehabilitation with the programme) or to a control group (no cognitive rehabilitation). Randomization was stratified by cognitive impairment level. Cognitive assessment included: selective reminding test, 10/36 spatial recall test (10/36 SPART), symbol digit modalities test, paced auditory serial addition test, word list generation (WLG), FAS test, subtests of WAIS-III, Boston naming test (BNT), and trail making test (TMT). Results: Forty-three patients (22 in the experimental group, 21 in the control group) were analyzed. Covariance analysis showed significant differences in 10/36 SPART (P=0.0002), 10/36 SPART delayed recall (P=0.0021), WLG (P=0.0123), LNS (P=0.0413), BNT (P=0.0007) and TMT-A (P=0.010) scores between groups. Conclusions: The study showed a significant improvement related to learning and visual memory, executive functions, attention and information processing speed, and naming ability in those patients who received cognitive rehabilitation. The results suggest that MS-Line! is effective in improving cognitive impairment in MS patients.
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