Journal
ANNUAL REVIEW OF MICROBIOLOGY, VOL 69
Volume 69, Issue -, Pages 463-485Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-micro-091014-104100
Keywords
Apicomplexa; invasion; egress; endodyogeny; IRG; inflammasome
Categories
Funding
- NIAID NIH HHS [F32 AI108251, R01AI081924, R21AI099658, R01 AI081924, R21 AI081220, R03 AI107475, R03AI107475, R01AI069986, R21 AI107257, R01 AI069986, R21 AI099658, R21AI107257, F32AI108251] Funding Source: Medline
- HSRD VA [RRP 12-175] Funding Source: Medline
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Toxoplasmosis is the clinical and pathological consequence of acute infection with the obligate intracellular apicomplexan parasite Toxoplasma gondii. Symptoms result from tissue destruction that accompanies lytic parasite growth. This review updates current understanding of the host cell invasion, parasite replication, and eventual egress that constitute the lytic cycle, as well as the ways T. gondii manipulates host cells to ensure its survival. Since the publication of a previous iteration of this review 15 years ago, important advances have been made in our molecular understanding of parasite growth and mechanisms of host cell egress, and knowledge of the parasite s manipulation of the host has rapidly progressed. Here we cover molecular advances and current conceptual frameworks that include each of these topics, with an eye to what may be known 15 years from now.
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