Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 21, Issue 13, Pages 1618-1625Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458515606526
Keywords
Pediatric; multiple sclerosis; physical activity; outcome; fatigue; depression; exercise; review
Categories
Funding
- National MS Society
- Canadian Institutes of Health Research
- Dairy Farmers of Ontario
- SickKids Foundation
- SickKids Innovation Fund
- CMSMS/PHAC
- Canadian Multiple Sclerosis Scientific Research Foundation
- MS Society of Canada
- National Institutes of Health
- Consortium of MS Centers
- Acorda Therapeutics
- Biogen Idec
- Sun Health Technologies
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Three-quarters of children with multiple sclerosis (MS) experience fatigue or depression, and progressive neurocognitive decline may be seen as early as two years after MS diagnosis. Furthermore, a higher magnetic resonance imaging disease burden is seen in pediatric-onset MS compared with adult-onset MS. To date, limited knowledge exists regarding behavioral methods for managing symptoms and disease progression in pediatric MS. To that end, this paper builds an evidence-based argument for the possible symptomatic and disease-modifying effects of exercise and physical activity in pediatric MS. This will be accomplished through: (a) a review of pediatric MS and its consequences; (b) a brief overview of physical activity and its consequences in children and adults with MS; and (c) a selective review of research on the neurological benefits of physical activity in pediatric populations. This topical review concludes with a list of 10 questions to guide future research on physical activity and pediatric MS. The objective of this paper is the provision of a research interest, focus and agenda involving pediatric MS and its lifelong management though exercise and physical activity behavior. Such an agenda is critical as the effects and maintenance of physical activity and exercise track across the lifespan, particularly when developed in the early stages of life.
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