Journal
ANNUAL REVIEW OF MEDICINE, VOL 66
Volume 66, Issue -, Pages 373-386Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-med-070813-114317
Keywords
microbiota; transplantation; donor feces; fidaxomicin
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Clostridium difficile infection (CDI) is a serious complication of hospitalization and antibiotic use with a high mortality and very high costs. Despite appropriate treatment, a subset of patients develop chronic recurrent CDI. Some other patients develop severe and life-threatening colitis. The risk factors, pathogenesis, and treatment of recurrent CDI and severe CDI are discussed in this review. In particular, fecal microbiota transplantation (FMT) as a treatment strategy is outlined and a treatment algorithm incorporating FMT is described.
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