Journal
MUCOSAL IMMUNOLOGY
Volume 8, Issue 3, Pages 444-463Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/mi.2014.131
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Funding
- French Fondation pour la Recherche Medicale FRM''
- Stanford Pediatric Research Fund
- Arthritis National Research Foundation
- National Institutes of Health [K99AI110645, U19 AI104209, NS 080062]
- Lucile Packard Foundation for Children's Health
- Stanford NIH/NCRR CTSA [UL1 RR025744]
- Postdoctoral Fellowship for Research Abroad of the Japan Society for the Promotion of Science
- Tobacco-Related Disease Research Program at University of California
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Mast cells (MCs) are cells of hematopoietic origin that normally reside in mucosal tissues, often near epithelial cells, glands, smooth muscle cells, and nerves. Best known for their contributions to pathology during IgE-associated disorders such as food allergy, asthma, and anaphylaxis, MCs are also thought to mediate IgE-associated effector functions during certain parasite infections. However, various MC populations also can be activated to express functional programs-such as secreting preformed and/or newly synthesized biologically active products-in response to encounters with products derived from diverse pathogens, other host cells (including leukocytes and structural cells), damaged tissue, or the activation of the complement or coagulation systems, as well as by signals derived from the external environment (including animal toxins, plant products, and physical agents). In this review, we will discuss evidence suggesting that MCs can perform diverse effector and immunoregulatory roles that contribute to homeostasis or pathology in mucosal tissues.
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