Journal
ANNUAL REVIEW OF GENETICS, VOL 49
Volume 49, Issue -, Pages 71-94Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-genet-120213-092053
Keywords
natural product; secondary metabolite; synthetic biology; combinatorial biosynthesis; compartmentalization
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Funding
- Biotechnology and Biological Sciences Research Council [BB/M004570/1] Funding Source: Medline
- BBSRC [BB/M004570/1] Funding Source: UKRI
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Secondary (specialized) metabolites, produced by bacteria, fungi, plants, and other organisms, exhibit enormous structural variation, and consequently display a wide range of biological activities. Secondary metabolism improves and modulates the phenotype of the host producer. Furthermore, these biological activities have resulted in the use of secondary metabolites in a variety of industrial and pharmaceutical applications. Metabolic engineering presents a powerful strategy to improve access to these valuable molecules. A critical overview of engineering approaches in secondary metabolism is presented, both in heterologous and native hosts. The recognition of the increasing role of compartmentalization in metabolic engineering is highlighted. Engineering approaches to modify the structure of key secondary metabolite classes are also critically evaluated.
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