Journal
ANNUAL REVIEW OF GENETICS, VOL 49
Volume 49, Issue -, Pages 627-646Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-genet-112414-055008
Keywords
nuclear organization; chromatin looping; transcription
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM069462] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM069462] Funding Source: Medline
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The packaging and organization of the genome within the eukaryotic interphase nucleus directly influence how the genes are expressed. An underappreciated aspect of genome structure is that it is highly dynamic and that the physical positioning of a gene can impart control over its transcriptional status. In this review, we assess the current knowledge of how gene positioning at different levels of genome organization can directly influence gene expression during interphase. The levels of organization discussed include chromatin looping, topologically associated domains, chromosome territories, and nuclear compartments. We discuss specific studies demonstrating that gene positioning is a dynamic and highly regulated feature of the eukaryotic genome that allows for the essential spatiotemporal regulation of genes.
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