Journal
MOVEMENT DISORDERS
Volume 30, Issue 6, Pages 843-847Publisher
WILEY-BLACKWELL
DOI: 10.1002/mds.26134
Keywords
Parkinson's disease; eye movements; antisaccades; executive function; task switching
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Funding
- National Institute of Health Research (NIHR)
- Dementias and Neurodegenerative Diseases Research Network (DENDRON)
- Wellcome Trust
- Monument Trust Discovery Award from Parkinson's UK
- National Institute for Health Research (NIHR) Oxford Biomedical Research Centre based at Oxford University Hospitals National Health Service (NHS) Trust
- University of Oxford
- National Institute for Health Research (NIHR) Oxford Biomedical Research Centre
- Parkinson's UK [J-0901, J-1403] Funding Source: researchfish
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BackgroundCognitive impairment is well recognized in Parkinson's disease (PD), but when it begins to develop is unclear. The aim of this study was to identify early signs of cognitive impairment along with abnormalities in saccadic behavior in newly diagnosed unmedicated PD patients. MethodsNineteen drug-naive PD patients and 20 controls were examined using a battery of tests, including an antisaccade task, phonemic and semantic verbal fluencies, and a switching and rule finding task. ResultsWith simple tasks, no differences were found between the two groups. However, cognitive performance of the two groups diverged with more complex tasks, occurring independently of PD-related motor impairment. Patients exhibited higher antisaccadic error rates and switch costs in the task switching test, and performed significantly worse in the rule finding task. ConclusionsCertain cognitive domains and saccadic parameters are already significantly impoverished in newly diagnosed Parkinson's patients, even before the initiation of medication. (c) 2015 International Parkinson and Movement Disorder Society
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