Journal
MOVEMENT DISORDERS
Volume 30, Issue 8, Pages 1068-1076Publisher
WILEY
DOI: 10.1002/mds.26171
Keywords
Parkinson's disease; substantia nigra; dorsolateral nigral hyperintensity; multiple system atrophy; progressive supranuclear palsy
Categories
Funding
- Oesterreichische Nationalbank (Austrian Central Bank, Anniversary Fund) [14171]
- Austrian Science Fund (FWF: Der Wissenschaftsfonds) [KLI82-B00]
- Austrian Science Fund (FWF) [KLI82] Funding Source: Austrian Science Fund (FWF)
- Austrian Science Fund (FWF) [KLI 82] Funding Source: researchfish
Ask authors/readers for more resources
BackgroundAbsence of a hyperintense, ovoid area within the dorsolateral border of the otherwise hypointense pars compacta of the substantia nigra (referred to as dorsolateral nigral hyperintensity) on iron-sensitive high-field magnetic resonance imaging sequences seems to be a typical finding for patients with Parkinson's disease (PD). ObjectiveThis study was undertaken to evaluate the diagnostic value of the dorsolateral nigral hyperintensity in a cohort of patients with neurodegenerative parkinsonism including PD, multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) as well as healthy controls using high-field susceptibility-weighted imaging (SWI) at 3.0 Tesla (T). MethodsAbsence of dorsolateral nigral hyperintensity was assessed on visual inspection of anonymized 3.0T SWI scans in a case-control study including 148 patients with neurodegenerative parkinsonism (PD: n=104; MSA: n=22; PSP: n=22) and 42 healthy controls. ResultsDorsolateral nigral hyperintensity was absent unilaterally in all patients with MSA or PSP, in 83 of 90 patients with PD, but only in one of the healthy controls resulting in an overall correct classification of 95.2% in discriminating neurodegenerative parkinsonism from controls in the per-protocol analysis. Overall correct classification was 93.2% in the intent-to-diagnose analysis, including also SWI scans with poor quality (12.1% of all scans) for nigral evaluation. ConclusionVisual assessment of dorsolateral nigral hyperintensity on high-field SWI scans may serve as a new simple diagnostic imaging marker for neurodegenerative parkinsonian disorders. (c) 2015 International Parkinson and Movement Disorder Society
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available