Journal
ANNUAL REVIEW OF FLUID MECHANICS, VOL 47
Volume 47, Issue -, Pages 405-429Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-fluid-010814-014658
Keywords
drops; bubbles; surfactants; biomedicine; acoustics; microfluidic devices
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We provide a comprehensive and systematic description of the diverse microbubble generation methods recently developed to satisfy emerging technological, pharmaceutical, and medical demands. We first introduce a theoretical framework unifying the physics of bubble formation in the wide variety of existing types of generators. These devices are then classified according to the way the bubbling process is controlled: outer liquid flows (e.g., coflows, cross flows, and flow-focusing flows), acoustic forcing, and electric fields. We also address modern techniques developed to produce bubbles coated with surfactants and liquid shells. The stringent requirements to precisely control the bubbling frequency, the bubble size, and the properties of the coating make microfluidics the natural choice to implement such techniques.
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