Journal
JORNAL DE PEDIATRIA
Volume 89, Issue 2, Pages 151-157Publisher
SOC BRASIL PEDIATRIA
DOI: 10.1016/j.jped.2013.03.008
Keywords
Bone mineral density; Cystic fibrosis; Pulmonary function
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Funding
- CNPq
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Objective: To assess bone mineral density in patients with cystic fibrosis (CF), and to correlate it with possible intervening variables. Methods: Children and adolescents diagnosed with CF, aged 6 to 18 years, followed at the outpatient clinic were included in the study. First, demographic data were collected and, subsequently, patients underwent a spirometric test. All patients answered the Cystic Fibrosis Quality of Life Questionnaire (CFQ) and underwent the six-minute walk test (6MWT) and bone densitometry (DXA). Results: A total of 25 CF patients were included, of which 56% were males. The mean age was 12.3 +/- 3.4 years; mean height was 149.2 +/- 14.4 cm; and mean weight was 44.4 +/- 13.9 kg. Most results on pulmonary function and bone mineral density (BMD) were within normal limits. The mean forced expiratory volume in one second (FEV1) was 92.5 +/- 23.6 (% of predicted), mean forced vital capacity (FVC) was 104.4 +/- 21.3 (% of predicted), and mean BMD z-score was 0.1 +/- 1.0. BMD was moderately correlated with FEV1 (r = 0.43, p = 0.03) and FVC (r = 0.57, p = 0.003). Regarding chronological age and age at diagnosis, a moderate and inverse correlation was also found (r = -0.55, p = 0.004; r = -0.57, p = 0.003, respectively). However, no significant correlations were found with the data from CFQ, 6MWT, and body mass index. Conclusion: Most patients had BMD within normal limits and presented a positive correlation with pulmonary function, as well as a negative correlation with chronological age and age at diagnosis. (C) 2013 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.
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