Journal
JOM
Volume 61, Issue 9, Pages 21-29Publisher
SPRINGER
DOI: 10.1007/s11837-009-0128-1
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Funding
- National Institute of Health [GM 072194-01]
- NSF [0826445]
- Yale Institute of Nanotechnology and Quantum Engineering seed grant
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The selection criteria for biomaterials include the material's properties and biocompatibility, and the ability to fabricate the desired shapes. Bulk metallic glasses (BMGs) are relative newcomers in the field of biomaterials but they exhibit an excellent combination of properties and processing capabilities desired for versatile implant applications. To further evaluate the suitability of BMGs for biomedical applications, we analyzed the biological responses they elicited in vitro and in vivo. The BMGs promoted cell adhesion and growth in vitro and induced improved foreign body responses in vivo suggesting their potential use as biomaterials. Because of the BMGs' flexible chemistry, atomic structure, and surface topography, they offer a unique opportunity to fabricate complex implants and devices with a desirable biological response from a material with superior properties over currently used metallic biomaterials.
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