Journal
JOM
Volume 61, Issue 6, Pages 12-16Publisher
SPRINGER
DOI: 10.1007/s11837-009-0081-z
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Funding
- U. S. Department of Energy [DE-AC09-08SR22470]
- Argonne National Laboratory (ANL) is a U. S. Department of Energy Office of Science Laboratory [DE-AC02-06CH11357]
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [0835577] Funding Source: National Science Foundation
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Nanostructured materials may play a significant role in controlled release of pharmacologic agents for treatment of cancer. Many nanoporous polymer materials are inadequate for use in drug delivery. Nanoporous alumina provides several advantages over other materials for use in controlled drug delivery and other medical applications. Atomic layer deposition was used to coat all the surfaces of a nanoporous alumina membrane in order to reduce the pore size in a controlled manner. Neither the 20 nm nor the 100 nm TiO2-coated nanoporous alumina membranes exhibited statistically lower viability compared to the uncoated nanoporous alumina membrane control materials. Nanostructured materials prepared using atomic layer deposition may be useful for delivering a pharmacologic agent at a precise rate to a specific location in the body. These materials may serve as the basis for smart drug delivery devices, orthopedic implants, or self-sterilizing medical devices.
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