Journal
JOINT BONE SPINE
Volume 78, Issue 2, Pages 184-187Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.jbspin.2010.05.009
Keywords
Ankylosing spondylitis; ADMA; Atherosclerosis; Cardiovascular disease
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Funding
- Debrecen University [OTKA K-72524, GVOP-3.2.1.-2004-04-0152/3.0, Mec-14/2005]
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Objective: Asymmetric dimethylarginine (ADMA) has been associated with atherosclerosis, vascular diseases and, recently, also with arthritis including rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Methods: Serum ADMA, arginine and symmetric dimethylarginine (SDMA) levels were assessed by liquid chromatography in 61 AS and 26 osteoarthritis (OA) patients with no known cardiovascular disease. Results: Serum ADMA levels were significantly increased in AS compared to OA patients (0.95 +/- 0.17 mu M versus 0.70 +/- 0.25 mu M; p < 0.001). There were no differences in serum arginine and SDMA levels. Serum ADMA levels also positively correlated with age (R = 0.258; p = 0.043), body mass index (R = 0.368; p = 0.003), erythrocyte sedimentation rate (R = 0.329; p = 0.009) and ADMA levels negative correlated with chest expansion (R = -0.251; p = 0.04). No correlations were found between ADMA levels and disease duration, pain intensity, BASDAI, BASFI, BASMI, quality of life, CRP, HLA-B27 positivity, endothelial dysfunction or carotid atherosclerosis. Conclusion: ADMA may serve as a marker of systemic inflammation and may reflect functional immobility in AS. Further studies are needed to assess the possible role of ADMA in AS and AS-related vascular disease. (C) 2010 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.,
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